Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations*
Identifieur interne : 002C57 ( Main/Exploration ); précédent : 002C56; suivant : 002C58Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations*
Auteurs : Satoshi Okada [États-Unis, Japon] ; Janet G. Markle [États-Unis] ; Elissa K. Deenick [Australie] ; Federico Mele [Suisse] ; Dina Averbuch [Israël] ; Macarena Lagos [Chili] ; Mohammed Alzahrani [Arabie saoudite] ; Saleh Al-Muhsen [Arabie saoudite] ; Rabih Halwani [Arabie saoudite] ; Cindy S. Ma [Australie] ; Natalie Wong [Australie] ; Claire Soudais [France] ; Lauren A. Henderson [États-Unis] ; Hiyam Marzouqa [Israël] ; Jamal Shamma [Israël] ; Marcela Gonzalez [Chili, Israël] ; Rubén Martinez-Barricarte [États-Unis] ; Chizuru Okada [États-Unis] ; Danielle T. Avery [Australie] ; Daniela Latorre [Suisse] ; Caroline Deswarte [France] ; Fabienne Jabot-Hanin [France] ; Egidio Torrado [États-Unis] ; Jeffrey Fountain [États-Unis] ; Aziz Belkadi [France] ; Yuval Itan [États-Unis] ; Bertrand Boisson [États-Unis] ; Mélanie Migaud [France] ; Cecilia S. Lindestam Arlehamn [États-Unis] ; Alessandro Sette [États-Unis] ; Sylvain Breton [France] ; James Mccluskey [Australie] ; Jamie Rossjohn [Australie, Royaume-Uni] ; Jean-Pierre De Villartay [France] ; Despina Moshous [France] ; Sophie Hambleton [Royaume-Uni] ; Sylvain Latour [France] ; Peter D. Arkwright [Royaume-Uni] ; Capucine Picard [États-Unis, France] ; Olivier Lantz [France] ; Dan Engelhard [Israël] ; Masao Kobayashi [Japon] ; Laurent Abel [États-Unis, France] ; Andrea M. Cooper [États-Unis] ; Luigi D. Notarangelo [États-Unis] ; Stéphanie Boisson-Dupuis [États-Unis, France] ; Anne Puel [États-Unis, France] ; Federica Sallusto [Suisse] ; Jacinta Bustamante [États-Unis, France] ; Stuart G. Tangye [Australie] ; Jean-Laurent Casanova [États-Unis, France]Source :
- Science (New York, N.Y.) [ 0036-8075 ] ; 2015.
Descripteurs français
- KwdFr :
- Allèles, Analyse de mutations d'ADN, Animaux, Bovins, Candida albicans (immunologie), Candidose mucocutanée chronique (), Candidose mucocutanée chronique (génétique), Candidose mucocutanée chronique (immunologie), Enfant, Enfant d'âge préscolaire, Exome (génétique), Femelle, Humains, Immunité (génétique), Immunodéficience combinée grave (génétique), Interféron gamma (immunologie), Interleukine-17 (immunologie), Lymphocytes T (immunologie), Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (génétique), Mutation, Mycobacterium bovis (immunologie), Mycobacterium bovis (isolement et purification), Mycobacterium tuberculosis (immunologie), Mycobacterium tuberculosis (isolement et purification), Pedigree, Réarrangement des gènes de la chaine alpha du récepteur pour l'antigène des cellules T, Récepteur lymphocytaire T antigène, alpha-bêta (génétique), Récepteur lymphocytaire T antigène, alpha-bêta (immunologie), Récepteur lymphocytaire T antigène, gamma-delta (génétique), Récepteur lymphocytaire T antigène, gamma-delta (immunologie), Souris, Thymus (glande) (immunologie), Thymus (glande) (malformations), Tuberculose bovine (génétique), Tuberculose bovine (immunologie), Tuberculose pulmonaire (génétique), Tuberculose pulmonaire (immunologie).
- MESH :
- génétique : Candidose mucocutanée chronique, Exome, Immunité, Immunodéficience combinée grave, Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires, Récepteur lymphocytaire T antigène, alpha-bêta, Récepteur lymphocytaire T antigène, gamma-delta, Tuberculose bovine, Tuberculose pulmonaire.
- immunologie : Candida albicans, Candidose mucocutanée chronique, Interféron gamma, Interleukine-17, Lymphocytes T, Mycobacterium bovis, Mycobacterium tuberculosis, Récepteur lymphocytaire T antigène, alpha-bêta, Récepteur lymphocytaire T antigène, gamma-delta, Thymus (glande), Tuberculose bovine, Tuberculose pulmonaire.
- isolement et purification : Mycobacterium bovis, Mycobacterium tuberculosis.
- malformations : Thymus (glande).
- Allèles, Analyse de mutations d'ADN, Animaux, Bovins, Candidose mucocutanée chronique, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mutation, Pedigree, Réarrangement des gènes de la chaine alpha du récepteur pour l'antigène des cellules T, Souris.
English descriptors
- KwdEn :
- Alleles, Animals, Candida albicans (immunology), Candidiasis, Chronic Mucocutaneous (complications), Candidiasis, Chronic Mucocutaneous (genetics), Candidiasis, Chronic Mucocutaneous (immunology), Cattle, Child, Child, Preschool, DNA Mutational Analysis, Exome (genetics), Female, Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor, Humans, Immunity (genetics), Interferon-gamma (immunology), Interleukin-17 (immunology), Mice, Mutation, Mycobacterium bovis (immunology), Mycobacterium bovis (isolation & purification), Mycobacterium tuberculosis (immunology), Mycobacterium tuberculosis (isolation & purification), Nuclear Receptor Subfamily 1, Group F, Member 3 (genetics), Pedigree, Receptors, Antigen, T-Cell, alpha-beta (genetics), Receptors, Antigen, T-Cell, alpha-beta (immunology), Receptors, Antigen, T-Cell, gamma-delta (genetics), Receptors, Antigen, T-Cell, gamma-delta (immunology), Severe Combined Immunodeficiency (genetics), T-Lymphocytes (immunology), Thymus Gland (abnormalities), Thymus Gland (immunology), Tuberculosis, Bovine (genetics), Tuberculosis, Bovine (immunology), Tuberculosis, Pulmonary (genetics), Tuberculosis, Pulmonary (immunology).
- MESH :
- chemical , genetics : Nuclear Receptor Subfamily 1, Group F, Member 3, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta.
- chemical , immunology : Interferon-gamma, Interleukin-17, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta.
- abnormalities : Thymus Gland.
- complications : Candidiasis, Chronic Mucocutaneous.
- genetics : Candidiasis, Chronic Mucocutaneous, Exome, Immunity, Severe Combined Immunodeficiency, Tuberculosis, Bovine, Tuberculosis, Pulmonary.
- immunology : Candida albicans, Candidiasis, Chronic Mucocutaneous, Mycobacterium bovis, Mycobacterium tuberculosis, T-Lymphocytes, Thymus Gland, Tuberculosis, Bovine, Tuberculosis, Pulmonary.
- isolation & purification : Mycobacterium bovis, Mycobacterium tuberculosis.
- Alleles, Animals, Cattle, Child, Child, Preschool, DNA Mutational Analysis, Female, Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor, Humans, Mice, Mutation, Pedigree.
Abstract
Human inborn errors of immunity mediated by the cytokines interleukin (IL)-17A/F underlie mucocutaneous candidiasis, whereas inborn errors of interferon (IFN)-γ immunity underlie mycobacterial disease. We report the discovery of bi-allelic
Url:
DOI: 10.1126/science.aaa4282
PubMed: 26160376
PubMed Central: 4668938
Affiliations:
- Arabie saoudite, Australie, Chili, France, Israël, Japon, Royaume-Uni, Suisse, États-Unis
- Angleterre, Californie, Grand Manchester, Massachusetts, Victoria (État), État de New York, Île-de-France
- Manchester, Melbourne, Paris
- Université de Manchester, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001D24
- to stream Pmc, to step Curation: 001B81
- to stream Pmc, to step Checkpoint: 000F20
- to stream PubMed, to step Corpus: 002A56
- to stream PubMed, to step Curation: 002986
- to stream PubMed, to step Checkpoint: 002986
- to stream Ncbi, to step Merge: 002820
- to stream Ncbi, to step Curation: 002820
- to stream Ncbi, to step Checkpoint: 002820
- to stream Main, to step Merge: 002C57
- to stream Main, to step Curation: 002C57
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impairment of immunity to <italic>Candida</italic> and <italic>Mycobacterium</italic> in humans with bi-allelic <italic>RORC</italic> mutations<sup><xref ref-type="fn" rid="FN3">*</xref></sup></title><author><name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Markle, Janet G" sort="Markle, Janet G" uniqKey="Markle J" first="Janet G." last="Markle">Janet G. Markle</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Mele, Federico" sort="Mele, Federico" uniqKey="Mele F" first="Federico" last="Mele">Federico Mele</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Averbuch, Dina" sort="Averbuch, Dina" uniqKey="Averbuch D" first="Dina" last="Averbuch">Dina Averbuch</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Pediatrics, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Lagos, Macarena" sort="Lagos, Macarena" uniqKey="Lagos M" first="Macarena" last="Lagos">Macarena Lagos</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago, Chile.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Chili</country><wicri:regionArea>Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Pediatrics, Padre Hurtado Hospital and Clinica Alemana, Santiago, Chile.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Chili</country><wicri:regionArea>Department of Pediatrics, Padre Hurtado Hospital and Clinica Alemana, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Alzahrani, Mohammed" sort="Alzahrani, Mohammed" uniqKey="Alzahrani M" first="Mohammed" last="Alzahrani">Mohammed Alzahrani</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Halwani, Rabih" sort="Halwani, Rabih" uniqKey="Halwani R" first="Rabih" last="Halwani">Rabih Halwani</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Natalie" sort="Wong, Natalie" uniqKey="Wong N" first="Natalie" last="Wong">Natalie Wong</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Soudais, Claire" sort="Soudais, Claire" uniqKey="Soudais C" first="Claire" last="Soudais">Claire Soudais</name><affiliation wicri:level="3"><nlm:aff id="A11">Institut Curie, INSERM U932, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Institut Curie, INSERM U932, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Henderson, Lauren A" sort="Henderson, Lauren A" uniqKey="Henderson L" first="Lauren A." last="Henderson">Lauren A. Henderson</name><affiliation wicri:level="2"><nlm:aff id="A12">Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Immunology, Boston Children's Hospital, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Marzouqa, Hiyam" sort="Marzouqa, Hiyam" uniqKey="Marzouqa H" first="Hiyam" last="Marzouqa">Hiyam Marzouqa</name><affiliation wicri:level="1"><nlm:aff id="A13">Caritas Baby Hospital, Post Office Box 11535, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Caritas Baby Hospital, Post Office Box 11535, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Shamma, Jamal" sort="Shamma, Jamal" uniqKey="Shamma J" first="Jamal" last="Shamma">Jamal Shamma</name><affiliation wicri:level="1"><nlm:aff id="A13">Caritas Baby Hospital, Post Office Box 11535, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Caritas Baby Hospital, Post Office Box 11535, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Marcela" sort="Gonzalez, Marcela" uniqKey="Gonzalez M" first="Marcela" last="Gonzalez">Marcela Gonzalez</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago, Chile.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Chili</country><wicri:regionArea>Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Pediatrics, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Barricarte, Ruben" sort="Martinez Barricarte, Ruben" uniqKey="Martinez Barricarte R" first="Rubén" last="Martinez-Barricarte">Rubén Martinez-Barricarte</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Okada, Chizuru" sort="Okada, Chizuru" uniqKey="Okada C" first="Chizuru" last="Okada">Chizuru Okada</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Latorre, Daniela" sort="Latorre, Daniela" uniqKey="Latorre D" first="Daniela" last="Latorre">Daniela Latorre</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Deswarte, Caroline" sort="Deswarte, Caroline" uniqKey="Deswarte C" first="Caroline" last="Deswarte">Caroline Deswarte</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jabot Hanin, Fabienne" sort="Jabot Hanin, Fabienne" uniqKey="Jabot Hanin F" first="Fabienne" last="Jabot-Hanin">Fabienne Jabot-Hanin</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Torrado, Egidio" sort="Torrado, Egidio" uniqKey="Torrado E" first="Egidio" last="Torrado">Egidio Torrado</name><affiliation wicri:level="2"><nlm:aff id="A16">Trudeau Institute, Saranac Lake, NY 12983, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Trudeau Institute, Saranac Lake, NY 12983</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fountain, Jeffrey" sort="Fountain, Jeffrey" uniqKey="Fountain J" first="Jeffrey" last="Fountain">Jeffrey Fountain</name><affiliation wicri:level="2"><nlm:aff id="A16">Trudeau Institute, Saranac Lake, NY 12983, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Trudeau Institute, Saranac Lake, NY 12983</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Belkadi, Aziz" sort="Belkadi, Aziz" uniqKey="Belkadi A" first="Aziz" last="Belkadi">Aziz Belkadi</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Itan, Yuval" sort="Itan, Yuval" uniqKey="Itan Y" first="Yuval" last="Itan">Yuval Itan</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Boisson, Bertrand" sort="Boisson, Bertrand" uniqKey="Boisson B" first="Bertrand" last="Boisson">Bertrand Boisson</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Mélanie" last="Migaud">Mélanie Migaud</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arlehamn, Cecilia S Lindestam" sort="Arlehamn, Cecilia S Lindestam" uniqKey="Arlehamn C" first="Cecilia S. Lindestam" last="Arlehamn">Cecilia S. Lindestam Arlehamn</name><affiliation wicri:level="2"><nlm:aff id="A17">La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name><affiliation wicri:level="2"><nlm:aff id="A17">La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Breton, Sylvain" sort="Breton, Sylvain" uniqKey="Breton S" first="Sylvain" last="Breton">Sylvain Breton</name><affiliation wicri:level="3"><nlm:aff id="A18">Department of Radiology, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Department of Radiology, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A22">Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="De Villartay, Jean Pierre" sort="De Villartay, Jean Pierre" uniqKey="De Villartay J" first="Jean-Pierre" last="De Villartay">Jean-Pierre De Villartay</name><affiliation wicri:level="3"><nlm:aff id="A23">Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name><affiliation wicri:level="3"><nlm:aff id="A23">Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hambleton, Sophie" sort="Hambleton, Sophie" uniqKey="Hambleton S" first="Sophie" last="Hambleton">Sophie Hambleton</name><affiliation wicri:level="1"><nlm:aff id="A25">Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle upon Tyne NE4 6BE, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle upon Tyne NE4 6BE</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne NE4 6BE</wicri:noRegion></affiliation></author><author><name sortKey="Latour, Sylvain" sort="Latour, Sylvain" uniqKey="Latour S" first="Sylvain" last="Latour">Sylvain Latour</name><affiliation wicri:level="3"><nlm:aff id="A26">Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name><affiliation wicri:level="4"><nlm:aff id="A27">Department of Paediatric Allergy Immunology, University of Manchester, Royal Manchester Children's Hospital, Manchester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Allergy Immunology, University of Manchester, Royal Manchester Children's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><affiliation wicri:level="3"><nlm:aff id="A11">Institut Curie, INSERM U932, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Institut Curie, INSERM U932, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Engelhard, Dan" sort="Engelhard, Dan" uniqKey="Engelhard D" first="Dan" last="Engelhard">Dan Engelhard</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Pediatrics, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cooper, Andrea M" sort="Cooper, Andrea M" uniqKey="Cooper A" first="Andrea M." last="Cooper">Andrea M. Cooper</name><affiliation wicri:level="2"><nlm:aff id="A16">Trudeau Institute, Saranac Lake, NY 12983, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Trudeau Institute, Saranac Lake, NY 12983</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D." last="Notarangelo">Luigi D. Notarangelo</name><affiliation wicri:level="2"><nlm:aff id="A12">Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Immunology, Boston Children's Hospital, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Manton Center for Orphan Disease Research, Children's Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Manton Center for Orphan Disease Research, Children's Hospital, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A30">Center of Medical Immunology, Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Center of Medical Immunology, Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A31">Howard Hughes Medical Institute, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26160376</idno><idno type="pmc">4668938</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668938</idno><idno type="RBID">PMC:4668938</idno><idno type="doi">10.1126/science.aaa4282</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D24</idno><idno type="wicri:Area/Pmc/Curation">001B81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B81</idno><idno type="wicri:Area/Pmc/Checkpoint">000F20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F20</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002A56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A56</idno><idno type="wicri:Area/PubMed/Curation">002986</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002986</idno><idno type="wicri:Area/PubMed/Checkpoint">002986</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002986</idno><idno type="wicri:Area/Ncbi/Merge">002820</idno><idno type="wicri:Area/Ncbi/Curation">002820</idno><idno type="wicri:Area/Ncbi/Checkpoint">002820</idno><idno type="wicri:doubleKey">0036-8075:2015:Okada S:impairment:of:immunity</idno><idno type="wicri:Area/Main/Merge">002C57</idno><idno type="wicri:Area/Main/Curation">002C57</idno><idno type="wicri:Area/Main/Exploration">002C57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impairment of immunity to <italic>Candida</italic> and <italic>Mycobacterium</italic> in humans with bi-allelic <italic>RORC</italic> mutations<sup><xref ref-type="fn" rid="FN3">*</xref></sup></title><author><name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Markle, Janet G" sort="Markle, Janet G" uniqKey="Markle J" first="Janet G." last="Markle">Janet G. Markle</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Mele, Federico" sort="Mele, Federico" uniqKey="Mele F" first="Federico" last="Mele">Federico Mele</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Averbuch, Dina" sort="Averbuch, Dina" uniqKey="Averbuch D" first="Dina" last="Averbuch">Dina Averbuch</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Pediatrics, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Lagos, Macarena" sort="Lagos, Macarena" uniqKey="Lagos M" first="Macarena" last="Lagos">Macarena Lagos</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago, Chile.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Chili</country><wicri:regionArea>Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Department of Pediatrics, Padre Hurtado Hospital and Clinica Alemana, Santiago, Chile.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Chili</country><wicri:regionArea>Department of Pediatrics, Padre Hurtado Hospital and Clinica Alemana, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Alzahrani, Mohammed" sort="Alzahrani, Mohammed" uniqKey="Alzahrani M" first="Mohammed" last="Alzahrani">Mohammed Alzahrani</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Halwani, Rabih" sort="Halwani, Rabih" uniqKey="Halwani R" first="Rabih" last="Halwani">Rabih Halwani</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country><wicri:regionArea>Department of Pediatrics, Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Natalie" sort="Wong, Natalie" uniqKey="Wong N" first="Natalie" last="Wong">Natalie Wong</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Soudais, Claire" sort="Soudais, Claire" uniqKey="Soudais C" first="Claire" last="Soudais">Claire Soudais</name><affiliation wicri:level="3"><nlm:aff id="A11">Institut Curie, INSERM U932, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Institut Curie, INSERM U932, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Henderson, Lauren A" sort="Henderson, Lauren A" uniqKey="Henderson L" first="Lauren A." last="Henderson">Lauren A. Henderson</name><affiliation wicri:level="2"><nlm:aff id="A12">Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Immunology, Boston Children's Hospital, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Marzouqa, Hiyam" sort="Marzouqa, Hiyam" uniqKey="Marzouqa H" first="Hiyam" last="Marzouqa">Hiyam Marzouqa</name><affiliation wicri:level="1"><nlm:aff id="A13">Caritas Baby Hospital, Post Office Box 11535, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Caritas Baby Hospital, Post Office Box 11535, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Shamma, Jamal" sort="Shamma, Jamal" uniqKey="Shamma J" first="Jamal" last="Shamma">Jamal Shamma</name><affiliation wicri:level="1"><nlm:aff id="A13">Caritas Baby Hospital, Post Office Box 11535, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Caritas Baby Hospital, Post Office Box 11535, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Marcela" sort="Gonzalez, Marcela" uniqKey="Gonzalez M" first="Marcela" last="Gonzalez">Marcela Gonzalez</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago, Chile.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Chili</country><wicri:regionArea>Department of Immunology, School of Medicine, Universidad de Valparaíso, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Pediatrics, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Barricarte, Ruben" sort="Martinez Barricarte, Ruben" uniqKey="Martinez Barricarte R" first="Rubén" last="Martinez-Barricarte">Rubén Martinez-Barricarte</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Okada, Chizuru" sort="Okada, Chizuru" uniqKey="Okada C" first="Chizuru" last="Okada">Chizuru Okada</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Latorre, Daniela" sort="Latorre, Daniela" uniqKey="Latorre D" first="Daniela" last="Latorre">Daniela Latorre</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Deswarte, Caroline" sort="Deswarte, Caroline" uniqKey="Deswarte C" first="Caroline" last="Deswarte">Caroline Deswarte</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jabot Hanin, Fabienne" sort="Jabot Hanin, Fabienne" uniqKey="Jabot Hanin F" first="Fabienne" last="Jabot-Hanin">Fabienne Jabot-Hanin</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Torrado, Egidio" sort="Torrado, Egidio" uniqKey="Torrado E" first="Egidio" last="Torrado">Egidio Torrado</name><affiliation wicri:level="2"><nlm:aff id="A16">Trudeau Institute, Saranac Lake, NY 12983, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Trudeau Institute, Saranac Lake, NY 12983</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fountain, Jeffrey" sort="Fountain, Jeffrey" uniqKey="Fountain J" first="Jeffrey" last="Fountain">Jeffrey Fountain</name><affiliation wicri:level="2"><nlm:aff id="A16">Trudeau Institute, Saranac Lake, NY 12983, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Trudeau Institute, Saranac Lake, NY 12983</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Belkadi, Aziz" sort="Belkadi, Aziz" uniqKey="Belkadi A" first="Aziz" last="Belkadi">Aziz Belkadi</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Itan, Yuval" sort="Itan, Yuval" uniqKey="Itan Y" first="Yuval" last="Itan">Yuval Itan</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Boisson, Bertrand" sort="Boisson, Bertrand" uniqKey="Boisson B" first="Bertrand" last="Boisson">Bertrand Boisson</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Mélanie" last="Migaud">Mélanie Migaud</name><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arlehamn, Cecilia S Lindestam" sort="Arlehamn, Cecilia S Lindestam" uniqKey="Arlehamn C" first="Cecilia S. Lindestam" last="Arlehamn">Cecilia S. Lindestam Arlehamn</name><affiliation wicri:level="2"><nlm:aff id="A17">La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name><affiliation wicri:level="2"><nlm:aff id="A17">La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Breton, Sylvain" sort="Breton, Sylvain" uniqKey="Breton S" first="Sylvain" last="Breton">Sylvain Breton</name><affiliation wicri:level="3"><nlm:aff id="A18">Department of Radiology, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Department of Radiology, Assistance Publique–Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><affiliation wicri:level="4"><nlm:aff id="A19">Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation wicri:level="1"><nlm:aff id="A20">Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A22">Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="De Villartay, Jean Pierre" sort="De Villartay, Jean Pierre" uniqKey="De Villartay J" first="Jean-Pierre" last="De Villartay">Jean-Pierre De Villartay</name><affiliation wicri:level="3"><nlm:aff id="A23">Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name><affiliation wicri:level="3"><nlm:aff id="A23">Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratoire Dynamique du Génome et Système Immunitaire, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hambleton, Sophie" sort="Hambleton, Sophie" uniqKey="Hambleton S" first="Sophie" last="Hambleton">Sophie Hambleton</name><affiliation wicri:level="1"><nlm:aff id="A25">Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle upon Tyne NE4 6BE, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University and Great North Children's Hospital, Newcastle upon Tyne NE4 6BE</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne NE4 6BE</wicri:noRegion></affiliation></author><author><name sortKey="Latour, Sylvain" sort="Latour, Sylvain" uniqKey="Latour S" first="Sylvain" last="Latour">Sylvain Latour</name><affiliation wicri:level="3"><nlm:aff id="A26">Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Université Paris Descartes–Sorbonne Paris Cité, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name><affiliation wicri:level="4"><nlm:aff id="A27">Department of Paediatric Allergy Immunology, University of Manchester, Royal Manchester Children's Hospital, Manchester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Allergy Immunology, University of Manchester, Royal Manchester Children's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><affiliation wicri:level="3"><nlm:aff id="A11">Institut Curie, INSERM U932, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Institut Curie, INSERM U932, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Engelhard, Dan" sort="Engelhard, Dan" uniqKey="Engelhard D" first="Dan" last="Engelhard">Dan Engelhard</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Israël</country><wicri:regionArea>Department of Pediatrics, Hadassah University Hospital, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea>Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cooper, Andrea M" sort="Cooper, Andrea M" uniqKey="Cooper A" first="Andrea M." last="Cooper">Andrea M. Cooper</name><affiliation wicri:level="2"><nlm:aff id="A16">Trudeau Institute, Saranac Lake, NY 12983, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Trudeau Institute, Saranac Lake, NY 12983</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D." last="Notarangelo">Luigi D. Notarangelo</name><affiliation wicri:level="2"><nlm:aff id="A12">Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Immunology, Boston Children's Hospital, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Manton Center for Orphan Disease Research, Children's Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Manton Center for Orphan Disease Research, Children's Hospital, Boston, MA 02115</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name><affiliation wicri:level="1"><nlm:aff id="A5">Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A30">Center of Medical Immunology, Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona, Switzerland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Suisse</country><wicri:regionArea>Center of Medical Immunology, Institute for Research in Biomedicine, University of Italian Switzerland, Bellinzona</wicri:regionArea><wicri:noRegion>Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Center for the Study of Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><affiliation wicri:level="1"><nlm:aff id="A3">Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="2"><nlm:aff id="A1">St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A15">Paris Descartes University, Imagine Institute, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Paris Descartes University, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Pediatric Hematology-Immunology Unit, AP-HP, Necker Hospital for Sick Children, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A31">Howard Hughes Medical Institute, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Animals</term><term>Candida albicans (immunology)</term><term>Candidiasis, Chronic Mucocutaneous (complications)</term><term>Candidiasis, Chronic Mucocutaneous (genetics)</term><term>Candidiasis, Chronic Mucocutaneous (immunology)</term><term>Cattle</term><term>Child</term><term>Child, Preschool</term><term>DNA Mutational Analysis</term><term>Exome (genetics)</term><term>Female</term><term>Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor</term><term>Humans</term><term>Immunity (genetics)</term><term>Interferon-gamma (immunology)</term><term>Interleukin-17 (immunology)</term><term>Mice</term><term>Mutation</term><term>Mycobacterium bovis (immunology)</term><term>Mycobacterium bovis (isolation & purification)</term><term>Mycobacterium tuberculosis (immunology)</term><term>Mycobacterium tuberculosis (isolation & purification)</term><term>Nuclear Receptor Subfamily 1, Group F, Member 3 (genetics)</term><term>Pedigree</term><term>Receptors, Antigen, T-Cell, alpha-beta (genetics)</term><term>Receptors, Antigen, T-Cell, alpha-beta (immunology)</term><term>Receptors, Antigen, T-Cell, gamma-delta (genetics)</term><term>Receptors, Antigen, T-Cell, gamma-delta (immunology)</term><term>Severe Combined Immunodeficiency (genetics)</term><term>T-Lymphocytes (immunology)</term><term>Thymus Gland (abnormalities)</term><term>Thymus Gland (immunology)</term><term>Tuberculosis, Bovine (genetics)</term><term>Tuberculosis, Bovine (immunology)</term><term>Tuberculosis, Pulmonary (genetics)</term><term>Tuberculosis, Pulmonary (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term><term>Analyse de mutations d'ADN</term><term>Animaux</term><term>Bovins</term><term>Candida albicans (immunologie)</term><term>Candidose mucocutanée chronique ()</term><term>Candidose mucocutanée chronique (génétique)</term><term>Candidose mucocutanée chronique (immunologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Exome (génétique)</term><term>Femelle</term><term>Humains</term><term>Immunité (génétique)</term><term>Immunodéficience combinée grave (génétique)</term><term>Interféron gamma (immunologie)</term><term>Interleukine-17 (immunologie)</term><term>Lymphocytes T (immunologie)</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires (génétique)</term><term>Mutation</term><term>Mycobacterium bovis (immunologie)</term><term>Mycobacterium bovis (isolement et purification)</term><term>Mycobacterium tuberculosis (immunologie)</term><term>Mycobacterium tuberculosis (isolement et purification)</term><term>Pedigree</term><term>Réarrangement des gènes de la chaine alpha du récepteur pour l'antigène des cellules T</term><term>Récepteur lymphocytaire T antigène, alpha-bêta (génétique)</term><term>Récepteur lymphocytaire T antigène, alpha-bêta (immunologie)</term><term>Récepteur lymphocytaire T antigène, gamma-delta (génétique)</term><term>Récepteur lymphocytaire T antigène, gamma-delta (immunologie)</term><term>Souris</term><term>Thymus (glande) (immunologie)</term><term>Thymus (glande) (malformations)</term><term>Tuberculose bovine (génétique)</term><term>Tuberculose bovine (immunologie)</term><term>Tuberculose pulmonaire (génétique)</term><term>Tuberculose pulmonaire (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nuclear Receptor Subfamily 1, Group F, Member 3</term><term>Receptors, Antigen, T-Cell, alpha-beta</term><term>Receptors, Antigen, T-Cell, gamma-delta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon-gamma</term><term>Interleukin-17</term><term>Receptors, Antigen, T-Cell, alpha-beta</term><term>Receptors, Antigen, T-Cell, gamma-delta</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Thymus Gland</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Candidiasis, Chronic Mucocutaneous</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Candidiasis, Chronic Mucocutaneous</term><term>Exome</term><term>Immunity</term><term>Severe Combined Immunodeficiency</term><term>Tuberculosis, Bovine</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Candidose mucocutanée chronique</term><term>Exome</term><term>Immunité</term><term>Immunodéficience combinée grave</term><term>Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires</term><term>Récepteur lymphocytaire T antigène, alpha-bêta</term><term>Récepteur lymphocytaire T antigène, gamma-delta</term><term>Tuberculose bovine</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Candida albicans</term><term>Candidose mucocutanée chronique</term><term>Interféron gamma</term><term>Interleukine-17</term><term>Lymphocytes T</term><term>Mycobacterium bovis</term><term>Mycobacterium tuberculosis</term><term>Récepteur lymphocytaire T antigène, alpha-bêta</term><term>Récepteur lymphocytaire T antigène, gamma-delta</term><term>Thymus (glande)</term><term>Tuberculose bovine</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Candida albicans</term><term>Candidiasis, Chronic Mucocutaneous</term><term>Mycobacterium bovis</term><term>Mycobacterium tuberculosis</term><term>T-Lymphocytes</term><term>Thymus Gland</term><term>Tuberculosis, Bovine</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Mycobacterium bovis</term><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Mycobacterium bovis</term><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Thymus (glande)</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Animals</term><term>Cattle</term><term>Child</term><term>Child, Preschool</term><term>DNA Mutational Analysis</term><term>Female</term><term>Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor</term><term>Humans</term><term>Mice</term><term>Mutation</term><term>Pedigree</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Analyse de mutations d'ADN</term><term>Animaux</term><term>Bovins</term><term>Candidose mucocutanée chronique</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mutation</term><term>Pedigree</term><term>Réarrangement des gènes de la chaine alpha du récepteur pour l'antigène des cellules T</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Human inborn errors of immunity mediated by the cytokines interleukin (IL)-17A/F underlie mucocutaneous candidiasis, whereas inborn errors of interferon (IFN)-γ immunity underlie mycobacterial disease. We report the discovery of bi-allelic <italic>RORC</italic> loss-of-function mutations in seven individuals from three kindreds of different ethnic origins with both candidiasis and mycobacteriosis. The lack of functional RORγ and RORγT isoforms resulted in the absence of IL-17A/F-producing T cells in these individuals, probably accounting for their chronic candidiasis. Unexpectedly, leukocytes from RORγ- and RORγT-deficient individuals also displayed an impaired IFN-γ response to <italic>Mycobacterium</italic>. This principally reflected profoundly defective IFN-γ production by circulating γδ T cells and CD4<sup>+</sup>CCR6<sup>+</sup> CXCR3<sup>+</sup> αβ T cells. In humans, both mucocutaneous immunity to <italic>Candida</italic> and systemic immunity to <italic>Mycobacterium</italic> require RORγ, or RORγT, or both.</p></div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Australie</li><li>Chili</li><li>France</li><li>Israël</li><li>Japon</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Grand Manchester</li><li>Massachusetts</li><li>Victoria (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Manchester</li><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université de Manchester</li><li>Université de Melbourne</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name></region><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><name sortKey="Arlehamn, Cecilia S Lindestam" sort="Arlehamn, Cecilia S Lindestam" uniqKey="Arlehamn C" first="Cecilia S. Lindestam" last="Arlehamn">Cecilia S. Lindestam Arlehamn</name><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><name sortKey="Boisson, Bertrand" sort="Boisson, Bertrand" uniqKey="Boisson B" first="Bertrand" last="Boisson">Bertrand Boisson</name><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Cooper, Andrea M" sort="Cooper, Andrea M" uniqKey="Cooper A" first="Andrea M." last="Cooper">Andrea M. Cooper</name><name sortKey="Fountain, Jeffrey" sort="Fountain, Jeffrey" uniqKey="Fountain J" first="Jeffrey" last="Fountain">Jeffrey Fountain</name><name sortKey="Henderson, Lauren A" sort="Henderson, Lauren A" uniqKey="Henderson L" first="Lauren A." last="Henderson">Lauren A. Henderson</name><name sortKey="Itan, Yuval" sort="Itan, Yuval" uniqKey="Itan Y" first="Yuval" last="Itan">Yuval Itan</name><name sortKey="Markle, Janet G" sort="Markle, Janet G" uniqKey="Markle J" first="Janet G." last="Markle">Janet G. Markle</name><name sortKey="Martinez Barricarte, Ruben" sort="Martinez Barricarte, Ruben" uniqKey="Martinez Barricarte R" first="Rubén" last="Martinez-Barricarte">Rubén Martinez-Barricarte</name><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D." last="Notarangelo">Luigi D. Notarangelo</name><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D." last="Notarangelo">Luigi D. Notarangelo</name><name sortKey="Okada, Chizuru" sort="Okada, Chizuru" uniqKey="Okada C" first="Chizuru" last="Okada">Chizuru Okada</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name><name sortKey="Torrado, Egidio" sort="Torrado, Egidio" uniqKey="Torrado E" first="Egidio" last="Torrado">Egidio Torrado</name></country><country name="Japon"><noRegion><name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name></noRegion><name sortKey="Kobayashi, Masao" sort="Kobayashi, Masao" uniqKey="Kobayashi M" first="Masao" last="Kobayashi">Masao Kobayashi</name></country><country name="Australie"><noRegion><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name></noRegion><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name><name sortKey="Avery, Danielle T" sort="Avery, Danielle T" uniqKey="Avery D" first="Danielle T." last="Avery">Danielle T. Avery</name><name sortKey="Deenick, Elissa K" sort="Deenick, Elissa K" uniqKey="Deenick E" first="Elissa K." last="Deenick">Elissa K. Deenick</name><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name><name sortKey="Mccluskey, James" sort="Mccluskey, James" uniqKey="Mccluskey J" first="James" last="Mccluskey">James Mccluskey</name><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name><name sortKey="Wong, Natalie" sort="Wong, Natalie" uniqKey="Wong N" first="Natalie" last="Wong">Natalie Wong</name><name sortKey="Wong, Natalie" sort="Wong, Natalie" uniqKey="Wong N" first="Natalie" last="Wong">Natalie Wong</name></country><country name="Suisse"><noRegion><name sortKey="Mele, Federico" sort="Mele, Federico" uniqKey="Mele F" first="Federico" last="Mele">Federico Mele</name></noRegion><name sortKey="Latorre, Daniela" sort="Latorre, Daniela" uniqKey="Latorre D" first="Daniela" last="Latorre">Daniela Latorre</name><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name></country><country name="Israël"><noRegion><name sortKey="Averbuch, Dina" sort="Averbuch, Dina" uniqKey="Averbuch D" first="Dina" last="Averbuch">Dina Averbuch</name></noRegion><name sortKey="Engelhard, Dan" sort="Engelhard, Dan" uniqKey="Engelhard D" first="Dan" last="Engelhard">Dan Engelhard</name><name sortKey="Gonzalez, Marcela" sort="Gonzalez, Marcela" uniqKey="Gonzalez M" first="Marcela" last="Gonzalez">Marcela Gonzalez</name><name sortKey="Marzouqa, Hiyam" sort="Marzouqa, Hiyam" uniqKey="Marzouqa H" first="Hiyam" last="Marzouqa">Hiyam Marzouqa</name><name sortKey="Shamma, Jamal" sort="Shamma, Jamal" uniqKey="Shamma J" first="Jamal" last="Shamma">Jamal Shamma</name></country><country name="Chili"><noRegion><name sortKey="Lagos, Macarena" sort="Lagos, Macarena" uniqKey="Lagos M" first="Macarena" last="Lagos">Macarena Lagos</name></noRegion><name sortKey="Gonzalez, Marcela" sort="Gonzalez, Marcela" uniqKey="Gonzalez M" first="Marcela" last="Gonzalez">Marcela Gonzalez</name><name sortKey="Lagos, Macarena" sort="Lagos, Macarena" uniqKey="Lagos M" first="Macarena" last="Lagos">Macarena Lagos</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Alzahrani, Mohammed" sort="Alzahrani, Mohammed" uniqKey="Alzahrani M" first="Mohammed" last="Alzahrani">Mohammed Alzahrani</name></noRegion><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name><name sortKey="Al Muhsen, Saleh" sort="Al Muhsen, Saleh" uniqKey="Al Muhsen S" first="Saleh" last="Al-Muhsen">Saleh Al-Muhsen</name><name sortKey="Halwani, Rabih" sort="Halwani, Rabih" uniqKey="Halwani R" first="Rabih" last="Halwani">Rabih Halwani</name></country><country name="France"><region name="Île-de-France"><name sortKey="Soudais, Claire" sort="Soudais, Claire" uniqKey="Soudais C" first="Claire" last="Soudais">Claire Soudais</name></region><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><name sortKey="Belkadi, Aziz" sort="Belkadi, Aziz" uniqKey="Belkadi A" first="Aziz" last="Belkadi">Aziz Belkadi</name><name sortKey="Belkadi, Aziz" sort="Belkadi, Aziz" uniqKey="Belkadi A" first="Aziz" last="Belkadi">Aziz Belkadi</name><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><name sortKey="Breton, Sylvain" sort="Breton, Sylvain" uniqKey="Breton S" first="Sylvain" last="Breton">Sylvain Breton</name><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="De Villartay, Jean Pierre" sort="De Villartay, Jean Pierre" uniqKey="De Villartay J" first="Jean-Pierre" last="De Villartay">Jean-Pierre De Villartay</name><name sortKey="Deswarte, Caroline" sort="Deswarte, Caroline" uniqKey="Deswarte C" first="Caroline" last="Deswarte">Caroline Deswarte</name><name sortKey="Deswarte, Caroline" sort="Deswarte, Caroline" uniqKey="Deswarte C" first="Caroline" last="Deswarte">Caroline Deswarte</name><name sortKey="Jabot Hanin, Fabienne" sort="Jabot Hanin, Fabienne" uniqKey="Jabot Hanin F" first="Fabienne" last="Jabot-Hanin">Fabienne Jabot-Hanin</name><name sortKey="Jabot Hanin, Fabienne" sort="Jabot Hanin, Fabienne" uniqKey="Jabot Hanin F" first="Fabienne" last="Jabot-Hanin">Fabienne Jabot-Hanin</name><name sortKey="Lantz, Olivier" sort="Lantz, Olivier" uniqKey="Lantz O" first="Olivier" last="Lantz">Olivier Lantz</name><name sortKey="Latour, Sylvain" sort="Latour, Sylvain" uniqKey="Latour S" first="Sylvain" last="Latour">Sylvain Latour</name><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Mélanie" last="Migaud">Mélanie Migaud</name><name sortKey="Migaud, Melanie" sort="Migaud, Melanie" uniqKey="Migaud M" first="Mélanie" last="Migaud">Mélanie Migaud</name><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name><name sortKey="Moshous, Despina" sort="Moshous, Despina" uniqKey="Moshous D" first="Despina" last="Moshous">Despina Moshous</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name></noRegion><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name><name sortKey="Hambleton, Sophie" sort="Hambleton, Sophie" uniqKey="Hambleton S" first="Sophie" last="Hambleton">Sophie Hambleton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C57 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002C57 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4668938
|texte= Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations*
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26160376" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |